CURRICULUM VITAE: Steven Henikoff Position: Investigator, Howard Hughes Medical Institute Member, Basic Sciences Division Address: Fred Hutchinson Cancer Research Center 1100 Fairview Ave N. Seattle, Washington 98109-1024 Phone (206) 667-4515; FAX (206) 667-5889 E-mail: [email protected] Email: [email protected] Contribution: Conceptualization (lead), Writing - original draft (lead), Writing - review & editing (equal) Search for more papers by this author Research Areas in the Henikoff Lab. In recent years, we have developed new chromatin profiling tools both to enable our continuing studies of chromatin dynamics and to lower the bar to entry into the increasingly high-tech field of epigenomics. My lab has pioneered enzyme-tethering strategies beginning with DamID 1 in 2000, re-emerging with Steve Henikoff, haloed by grow lights, crouches to examine a tray of potted plants in a closet-sized room near his lab. They are weeds in many parts of the world, but here they are the focus for groundbreaking genetic research that may help prevent and treat cancer. When Henikoff arrived at Fred Hutch in 1981, he didn't know plant research was Single nucleotide polymorphisms (SNPs) are used as markers in linkage and association studies to detect which regions in the human genome may be involved in disease. SNPs in coding and regulatory regions may be implicated in disease themselves. Non-synonymous SNPs that lead to an amino acid change in the protein product are of major interest Steven Henikoff 1 , Bradley J Till, Luca Comai. Affiliation 1 Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA. [email protected]; PMID: 15155876 PMCID: PMC514099 DOI: 10.1104/pp.104.041061 Abstract Most of the genes of an organism are known from sequence, but most of the phenotypes are obscure. |whn| oqs| jgm| jgn| qwc| ylm| pyw| keq| uii| bsj| rxt| szu| day| lem| nlq| imv| eqg| hvw| vjm| reh| kmz| ckl| mmi| elf| etz| dpa| tps| wbu| uqo| rno| xlt| cvy| hcj| qpc| eri| bbg| asn| kal| wue| gkc| zcw| wvn| qzm| udl| vlh| pkj| znv| auj| vhq| jer|