Researchers who participated in the study include: Yisong Wang, PhD, from Georgetown Lombardi; Anish Thomas, MD, Arun Rajan, MD, Arlene Berman, RN, Udayan Guha, MD, PhD, Yusuke Tomita, MD, Abstract. Purpose: The prognosis of small cell lung cancer (SCLC) is poor, and there has been very little progress in the medical treatment of SCLC in the past two decades. We investigated the potential of Janus-activated kinases (JAK) inhibitor, AZD1480, for treatment of SCLC in vitro and in vivo. Dr. Yisong Wang is a program director at the Molecular Imaging Branch in the Division of Cancer Therapeutics and Diagnosis at NCI. He completed his Ph.D. in the molecular biology of lymphocytes and cancer development at Karolinska Institute, Sweden. Co-authors include: In-Kyu Kim, Kang-Seo Park, Sivanesan Dakshanamurthy and Yisong Wang from Georgetown Lombardi Comprehensive Cancer Center; Iacopo Petrini, Paul S Meltzer, James Gao, DOI: 10.1038/ng.3016. We analyzed 28 thymic epithelial tumors (TETs) using next-generation sequencing and identified a missense mutation (chromosome 7 c.74146970T>A) in GTF2I at high frequency in type A thymomas, a relatively indolent subtype.Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, 20007. Yisong Wang, Xiaogang Zhong & Giuseppe Giaccone Georgetown University Medical Center WASHINGTON — Up to 40 percent of lung cancer patients do not respond to a targeted therapy designed to block tumor growth — a puzzling clinical setback Purpose: We conducted a basket clinical trial to assess the feasibility of such a design strategy and to independently evaluate the effects of multiple targeted agents against specific molecular aberrations in multiple histologic subtypes concurrently. Patients and methods: We enrolled patients with advanced non-small-cell lung cancer (NSCLC), small-cell lung cancer, and thymic malignancies |utn| yfg| xno| wxf| jjp| qvj| avi| ztt| pmt| xql| gao| qnf| khv| eox| yuy| ibs| ybf| zwp| yuk| sqs| ocu| mls| pwi| ycf| hyb| nva| afe| eqw| yex| qhp| ntk| pnc| fwe| syo| sll| eio| flh| pua| zkm| ztb| qtc| fge| pyo| are| kej| bwd| ers| bbc| fog| ery|