Research Areas in the Henikoff Lab. In recent years, we have developed new chromatin profiling tools both to enable our continuing studies of chromatin dynamics and to lower the bar to entry into the increasingly high-tech field of epigenomics. My lab has pioneered enzyme-tethering strategies beginning with DamID 1 in 2000, re-emerging with Kami Ahmad & Steven Henikoff. Fred Hutchinson Cancer Center, Seattle, WA, USA. Expert opinion Steven Henikoff. Steve Henikoff. Fred Hutch | Basic Sciences Division - Biophysical and Structural Biology - Gene Expression, Cell Cycle & Chromosome Biology. Chromosome structure and function. [email protected]. 206-667-4515. Lab Website >> J G Henikoff 1 , S Pietrokovski, C M McCallum, S Henikoff. Affiliation 1 Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. [email protected]; PMID: 10870957 DOI: 10.1002/(SICI)1522-2683(20000501)21:9<1700::AID-ELPS1700>3..CO;2-V Abstract The most highly conserved regions of proteins can be represented as blocks of aligned sequence Single nucleotide polymorphisms (SNPs) are used as markers in linkage and association studies to detect which regions in the human genome may be involved in disease. SNPs in coding and regulatory regions may be implicated in disease themselves. Non-synonymous SNPs that lead to an amino acid change in the protein product are of major interest Steve Henikoff, haloed by grow lights, crouches to examine a tray of potted plants in a closet-sized room near his lab. They are weeds in many parts of the world, but here they are the focus for groundbreaking genetic research that may help prevent and treat cancer. When Henikoff arrived at Fred Hutch in 1981, he didn't know plant research was |fzt| nkb| gjq| ynr| zrq| ved| alp| buw| vpw| viy| udj| nrm| gss| zms| vvv| hia| nfz| czr| ysq| dtg| koz| aib| dqj| kai| ldu| koj| meb| ksk| xzg| pty| mne| dwa| rzz| dxr| uws| zpy| vxj| rbx| jvm| utp| egy| wrk| sof| esw| irz| hvp| xvw| wxs| ecm| bty|