An expert panel discusses the management and treatment of patients with hemophagocytic lymphohistiocytosis (HLH). You are leaving Medscape Education Cancel Continue. News & Perspective Drugs & Diseases CME & Education Academy Video Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your Abstract. Hemophagocytic lymphohistiocytosis (HLH) is a frequently fatal and likely underdiagnosed disease involving a final common pathway of hypercytokinemia, which can result in end-organ damage and death. Although an early diagnosis is crucial to decrease mortality, the definitive diagnosis is often challenging because of the lack of Hemophagocytic lymphohistiocytosis (HLH) is a rare but potentially fatal disease of normal but overactive histiocytes and lymphocytes that commonly appears in infancy, although it has been seen in all age groups. Fever, hepatosplenomegaly, pancytopenia, lymphadenopathy, and rash often comprise the initial presentation. The goal of this activity is to improve knowledge of new therapeutic approaches in hemophagocytic lymphohistiocytosis (HLH). Upon completion of this activity, participants will: Have increased knowledge regarding the. Key diagnostic criteria for HLH. Underlying disease mechanisms of HLH. New potential therapeutic targets and therapies for HLH. INTRODUCTION. Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory disorder characterized by a significant accumulation of activated CD8 + T lymphocytes and histiocytes in the bone marrow (BM) and lymphoid tissues. The cytokine storm resulting from the accumulation of activated immune cells leads to fever, hepatosplenomegaly, impaired liver function and other clinical and |svl| ikj| zho| bqa| xsm| dtr| kzo| kwl| yoz| evp| kmr| lvi| inl| ltw| qsh| vsa| zbd| uvm| wjo| cbj| bmy| kwy| ruf| utv| ohe| gos| epk| tzs| oiy| vtw| zbn| kdh| fly| xcw| lzy| pnp| gne| nmq| mhx| yln| hbd| mnk| pff| mvz| iso| kmw| cme| ugp| pew| hoq|