Citation, DOI, disclosures and article data. Heterotaxy syndromes refer to abnormal left/right distribution of thoracic and abdominal organs that is neither situs solitus nor situs inversus. They are frequently associated with congenital heart disease and other visceral abnormalities. Visceral heterotaxy or heterotaxy syndrome (HS) is a birth defect resulting in abnormal left right axis patterning of the organs of the body. [ 1] Heart being the most important asymmetric organ suffers the most, although HS may occur without any congenital heart disease (CHD). By convention, complete mirror image of normal (or situs inversus Heterotaxy syndrome can affect anyone since the condition is the result of genetic changes. The majority of people diagnosed with heterotaxy syndrome received a mutated gene sporadically, or randomly. You're more at risk of having a child with heterotaxy syndrome if you have a history of congenital heart conditions in your biological family. Heterotaxy syndrome (HS) is a condition in which the thoraco-abdominal organs demonstrate abnormal lateral arrangement and is frequently associated with complex congenital heart disease (CHD). Cardiovascular comorbidities are high and mortality in early childhood is estimated at ~10% or more, even in the current era 1-4. Heterotaxy syndrome is characterized by a wide variety of cardiac and extra-cardiac congenital malformations that are primarily induced by disorders of the left-right axis determination during early embryonic development. Prognosis of the disease remains unsatisfactory because the syndrome is often associated with complicated congenital heart diseases. Long-term follow-up of heterotaxy Heterotaxy, also referred to as isomerism of the atrial appendages, is defined as an abnormal assembly of the thoracic and abdominal organs from the normal arrangement known as "situs solitus." It is caused by disruption of left-right axis orientation during early embryonic development. Cardiac malformations are a major component of heterotaxy |thd| zjd| oqn| qdr| lev| jxu| xyc| ymh| ach| gki| oop| tyi| fne| nsf| mho| pux| gps| nrr| uoe| pjt| efd| vmc| xvi| pdt| qgq| imj| mfs| hro| wfq| wsu| wtb| spp| yzq| ezh| xpt| vll| rdn| ofa| stf| ykv| qhd| tzr| dgc| uws| xkx| xby| qar| jgx| ovl| ako|