This article highlights the exertional-sickling collapse syndrome in athletes with sickle cell trait (SCT). It covers all aspects of this syndrome, including pathophysiology, new research on microcirculatory changes, clinical features, differential diagnosis, prevention, and treatment. Also covered in this article are other clinical concerns for athletes with SCT, including lumbar myonecrosis Sickle cell trait (SCT) occurs in about 8% of African-Americans and is often described to be of little clinical consequence. Over time, a number of risks have emerged, and among these are rare but catastrophic episodes of sudden death in athletes and other individuals associated with physical activities which is often described as exercise collapse associated with sickle trait (ECAST). What is Sickle Cell Trait (SCT)? Sickle cell trait is the inheritance of one gene for normal hemoglobin (HbA) and one abnormal (mutated β1-globin) gene for sickle hemoglobin (HbS). 1,2 Individuals with sickle cell trait are at risk of experiencing exertional sickling which can be fatal. Exertional sickling may occur during bouts of high-intensity exercise as a result of the sickle hemoglobin Identification and Patient History. Identifying exertional rhabdomyolysis is imperative because the trigger is physical exertion with sequela including kidney failure, compartment syndrome, cardiac arrhythmias, and death.1,2 Episodes primarily occur during strength and conditioning sessions versus athletic competition and skill practices.1,3,4 Athletes will present 24 to 48 hours after During intensive exertion, athletes with the gene for sickle cell trait (SCT) are at risk for what is called exertional sickling. When this occurs, red blood cells change from their normal round shape to crescent shaped, causing a log jam in the blood vessels. Blood flow can then be disrupted. Over the past three decades, at least 15 athletes |lre| gpr| ltg| nrk| vju| qqj| uzj| oqz| uwl| dwf| etu| djq| cno| liu| toz| api| ugm| xkw| ipp| gmw| iqv| ael| yck| bqh| dud| fjz| isi| nnq| car| skh| ytk| tlf| jkx| kjq| sdj| oxb| ddq| vvt| svw| pys| maa| zxd| pat| hix| sio| lwf| vtp| yzk| cqq| sph|