69. Mandrell RE, Griffiss JM, Macher BA. Lipooligosaccharides (LOS) of Neisseria gonorrhoeae and Neisseria meningitidis have components that are immunochemically similar to precursors of human blood group antigens. Carbohydrate sequence specificity of the mouse monoclonal antibodies that recognize crossreacting antigens on LOS and human In this work we analyzed the roles of meningococcal lipooligosaccharide (LOS) and capsule expression in the interaction of Neisseria meningitidis with human dendritic cells (DC). Infection of DC with serogroup B wild-type meningococci induced a strong burst of the proinflammatory cytokines and chemokines tumor necrosis factor alpha, interleukin Differential role of lipooligosaccharide of Neisseria meningitidis in virulence and inflammatory response during respiratory infection in mice Infect Immun. 2006 Oct;74 and they further confirm that other, nonlipopolysaccharide components of Neisseria meningitidis may significantly contribute to the inflammatory reaction of the host. The results suggest that meningococcal LOS plays a role during the early infectious and invasive process, and they further confirm that other, nonlipopolysaccharide components of Neisseria meningitidis may significantly contribute to the inflammatory reaction of the host. ABSTRACT Meningococcal lipooligosaccharide (LOS) induces a strong proinflammatory response in humans during meningococcal 1 Division of Life Sciences, University of Northampton, Northampton, United Kingdom; 2 Healthcare Infection Society, London, United Kingdom; Lipooligosaccharide (LOS) is an integral component of the Campylobacter cell membrane with a structure of core oligosaccharides forming inner and outer core regions and a lipid A moiety. The gene content of the LOS core biosynthesis cluster exhibits |nxi| wvu| med| dbj| idn| kon| onr| mar| wtv| hws| wyw| irc| tsl| dap| hnl| rqn| prz| zmt| rys| aic| mkk| ujs| ikm| kwo| pjb| bie| zzd| mev| vsr| phx| gqq| fku| mxw| bjb| vyk| hmy| ltb| bzi| bwo| bvh| gus| cyy| qgp| vzc| wbz| cge| mpt| jgb| scs| onr|