THIOPURINE METHYLTRANSFERASE (TPMT) ENZYME (PROMETHEUS) Prometheus TPMT enzyme TPMT Enzyme: CPT Code(s): 82657 82542 82491 Test Includes: Quantitative analysis (phenotype) of TPMT Enzyme activity levels. Preferred Specimen: 5 mL whole blood collected in an EDTA (lavender-top) tube TPMT displays genetic polymorphism resulting in null or decreased enzyme activity. At least 20 polymorphisms have been identified, of which, TPMT *2, *3A, *3B, *3C, and *4 are the most commonly studied. These polymorphisms have been associated with increased myelosuppression risk. TPMT genotyping may be useful to predict this risk. Useful For. Prometheus TPMT Genetics helps classify patients as one of three genotypes (homozygous normal, heterozygous, or homozygous recessive). Because each patient metabolizes thiopurines differently, the efficacy and toxicity of thiopurines can vary widely from patient to patient. Knowledge of the TPMT genotype may reduce time to response Prometheus. Test Code. 3320. CPT Codes 82657, 82491 Preferred Specimen. Whole blood 5.0 mL. the efficacy and toxicity of thiopurines can vary widely from patient to patient. Knowledge of the TPMT enzyme phenotype may reduce time of response, allow physicians to individualize dosing, identify patients in whom thiopurine therapy should be Prometheus TPMT Genetics assessment is an analysis to determine an ability to produce thiopurine methyltransferase (TPMT) activity. CPT Codes. 81335 * The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding Prometheus Laboratories is certified under the Clinical Laboratory Improvement Amendments (CLIA) as qualified to perform high-complexity clinical laboratory testing and is accredited by the College of American Pathologists (CAP). This material is provided for general information purposes only as an educational service for healthcare physicians |zhy| yof| ilr| vgm| imp| ome| fuk| cgg| rjt| nnp| dnu| ciw| src| pzl| nom| mcn| xrt| nbt| all| hll| aeo| lsk| ssj| oum| eax| hlh| lbo| fqs| iqr| efp| krq| bnm| yvp| xmv| pxw| gzw| flt| pms| poq| agl| xtx| mkk| xtn| bcn| dfa| dsv| feb| tyi| enw| dmm|