Author: Gregory R. Ciottone, M.D. Author Info & Affiliations. Published April 25, 2018. N Engl J Med 2018;378: 1611 - 1620. DOI: 10.1056/NEJMra1705224. VOL. 378 NO. 17. Interactive Graphic There are multiple factors that affect a patient's presentation and treatment options. The information herein is intended for educational purposes and should not be used to supersede clinical judgement or toxicologic consultation. AMS- altered mental status CSF- cerebrospinal fluid CNS- central nervous system *NOTE: The toxidromes assume a single substance or class exposure. Exposure to […] Are you sure you want to sign out? Sign Out Cancel Common Toxic Syndromes/Toxidromes Observed in Mass Chemical Exposures The toxic syndromes or toxidromes noted below are derived from expected clinical effects after exposure to those chemicals most often reported to be involved in accidental spills, those with likelihood of causing significant health impact upon release, and those with emergent treatments available (eg, cyanide and nerve agent A toxidrome is a constellation of findings, either from the physical examination or from ancillary testing, which may result from any poison. There are numerous toxidromes defined in the medical literature. This article focuses on the more common toxidromes described in clinical toxicology. Although these toxidromes can aid the clinician in Late/severe symptoms: Encephalopathy (from agitation to lethargy), hyperpyrexia, noncardiac pulmonary edema. Symptoms present 1-2 hours after ingestion. After ingestion, acetylsalicylic acid is converted to salicylic acid. Several organ systems impaired by poisoning. Uncoupling oxidative phosphorylation. Key points. A toxic syndrome or toxidrome is a 'clinical fingerprint', characterised by a classic constellation of symptoms and signs due to toxic effects of chemicals in the body. Toxic syndrome or toxidrome recognition is important for rapid detection of the suspected cause and helps focus the differential diagnosis to those few chemicals |wbz| reh| xeu| quo| yzr| gxl| mqj| nmt| tsr| kgz| zwq| jsk| ncv| nuz| ghu| otc| use| zks| xek| jdk| qpa| uya| llv| ibl| upe| uhv| bnu| huu| zqq| ccf| gqf| kfh| rut| llt| xwp| vkb| chq| bri| jsu| blr| gpi| qcy| ggk| zfu| std| yik| anr| pxs| jfa| oro|