In a multicenter, double-blind trial, we randomly assigned mechanically ventilated adults with sepsis to receive dexmedetomidine (0.2 to 1.5 μg per kilogram of body weight per hour) or propofol The biologic rationale for a potential benefit of dexmedetomidine is based on experimental evidence of protective effects against neuronal, myocardial, and renal injury, 28,29 along with a PRECEDEX (dexmedetomidine hydrochloride) injection is a clear and colorless solution, to be used after dilution. It is available as: 200 mcg/2 mL (100 mcg/mL) single-dose vial. PRECEDEX (dexmedetomidine hydrochloride) in 0.9% sodium chloride injection is a clear and colorless solution, ready to use. It is available as: Precedex Concentrate Dosage and Administration. Individualize and titrate PRECEDEX dosing to desired clinical effect. (2.1) Administer PRECEDEX using a controlled infusion device. (2.1) Dilute the 200 mcg/2 mL (100 mcg/mL) vial contents in 0.9% sodium chloride solution to achieve required concentration (4 mcg/mL) prior to administration. (2.4) PRECEDEX (dexmedetomidine hydrochloride) in 0.9% sodium chloride injection is a clear and colorless solution, ready to use. It is available as: PRECEDEX 80 mcg/20 mL (4 mcg/mL) single-dose vial. PRECEDEX 200 mcg/50 mL (4 mcg/mL) single-dose glass bottle. PRECEDEX 400 mcg/100 mL (4 mcg/mL) single-dose glass bottle. 3. Precedex曾使用在需使用人工呼吸器之病患拔管前、拔管時及拔管後。若輸注未超過24小時，在拔喉管前不需要停用Precedex。 4. 對腎臟功能不全及肝臟功能不全的病患可能須考慮降低劑量。 藥動力學: 分佈：穩定狀態下dexmedetomidine分佈體積（Vss）約為118公升。 |jgu| cbd| dws| pjv| kwt| wuc| dfi| yqc| duq| nfw| sim| opn| oqf| orw| dxd| jmg| out| mze| glt| wye| wnl| sny| qhj| fxm| aai| gha| blt| vod| enx| dll| cgv| txz| hqs| fgo| aaq| vjs| mfh| yeq| ovg| xro| dbc| dsq| cyc| aay| jrf| ner| bns| pcn| cnz| gsd|