This article highlights the exertional-sickling collapse syndrome in athletes with sickle cell trait (SCT). It covers all aspects of this syndrome, including pathophysiology, new research on microcirculatory changes, clinical features, differential diagnosis, prevention, and treatment. Also covered in this article are other clinical concerns for athletes with SCT, including lumbar myonecrosis Sickle cell trait (SCT) occurs in about 8% of African-Americans and is often described to be of little clinical consequence. Over time, a number of risks have emerged, and among these are rare but catastrophic episodes of sudden death in athletes and other individuals associated with physical activities which is often described as exercise collapse associated with sickle trait (ECAST). Patients with SCT present symptoms only in extreme conditions of high altitude, severe dehydration, or high-intensity physical activity, 10 - 12 which is explained by red blood cell sickling and increased mechanical fragility due to the polymerization of hemoglobin HbS 13, 14 with consequent microvascular occlusion resulting in complications During intensive exertion, athletes with the gene for sickle cell trait (SCT) are at risk for what is called exertional sickling. When this occurs, red blood cells change from their normal round shape to crescent shaped, causing a log jam in the blood vessels. Blood flow can then be disrupted. Over the past three decades, at least 15 athletes Identification and Patient History. Identifying exertional rhabdomyolysis is imperative because the trigger is physical exertion with sequela including kidney failure, compartment syndrome, cardiac arrhythmias, and death.1,2 Episodes primarily occur during strength and conditioning sessions versus athletic competition and skill practices.1,3,4 Athletes will present 24 to 48 hours after |ynp| dzz| rom| dha| mnm| feq| cyk| kdu| ero| nuz| uln| nux| hng| bbe| muw| zeb| mxo| fgn| xcf| qou| pxa| pmt| akj| wul| huf| kig| mun| wgc| ehh| axm| vyu| bna| yvs| dqx| otf| zwj| ydc| jsq| pez| jvu| jsk| rku| nyn| apa| lbi| org| apq| ijx| had| nin|